Amaryl

Brand: AMARYL

Generic: GLIMEPIRIDE

AMARYL is used to treat a certain form of diabetes (type 2 diabetes mellitus) when diet, physical exercise and weight reduction alone have not been able to control your blood sugar levels.

AMARYL GENERIC (origin: Netherlands) 30 tablets 2MG:  $ 3.00
AMARYL GENERIC (origin: Netherlands) 30 tablets 3MG:  $ 4.50
AMARYL GENERIC (origin: Netherlands) 30 tablets 4MG:  $ 6.00
CLICK HERE TO ORDER TODAY

MEDICATION GUIDE

  Amaryl Medication Guide (145.7 KiB, 35 hits)

SAFETY INFORMATION

►Do not take AMARYL and tell your doctor if:

• you are allergic (hypersensitive) to Glimepiride or other sulfonylureas (medicines used to lower your blood sugar such as glibenclamide) or sulfonamides (medicines for bacterial infections such as sulfamethoxazole) or any of the other ingredients of AMARYL
• you have insulin dependent diabetes (type 1 diabetes mellitus)
• you have diabetic ketoacidosis (a complication of diabetes when your acid level is raised in your body and you may have some of the following signs: fatigue, feeling sick (nausea), frequent urination and muscular stiffness)
• you are in a diabetic coma
• you have severe kidney disease
• you have a severe liver disease
• you are pregnant
• you are breast-feeding

►Check with your healthcare provider before taking AMARYL if:

• you are recovering from an injury, operation, infections with fever, or from other forms of stress, inform your doctor as temporary change of treatment may be necessary
• you have a severe liver or kidney disorder
• you cannot tolerate some sugars; AMARYL contains lactose

► Lowering of the haemoglobin level and breakdown of red blood cells (haemolytic anemia) can occur in patients missing the enzyme glucose-6-phosphate dehydrogenase.

► The information available on the use of AMARYL in people under 18 years of age is limited. Therefore, its use in these patients is not recommended.

►Important information about hypoglycaemia (low blood sugar)

When you take AMARYL, you may get hypoglycaemia (low blood sugar). Please see below for additional information about hypoglycaemia, its signs and treatment.

►Following factors could increase the risk of you getting hypoglycaemia:

• Undernourishment, irregular meal time, missed or delayed meal or period of fasting
• Changes to your diet
• Taking more AMARYL than needed
• Having kidneys that do not work properly
• Having severe liver disease
• If you suffer from particular hormone-induced disorders (disorders of the thyroid glands, of the pituitary gland or adrenal cortex)
• Drinking alcohol (especially when you skip a meal)
• Taking certain other medicines (See Taking other medicines below)
• If you increase the amount of exercise you do and you don’t eat enough food or eat food containing less carbohydrate than usual.

► Signs of hypoglycaemia include:

• Hunger pangs, headache, nausea, vomiting, sluggishness, sleepiness, problems sleeping, restlessness, aggression, problems with concentration, reduced alertness and reaction time, depression, confusion, problems with your speech and sight, slurred speech, shakiness, partial paralysis, dizziness, helplessness
• The following signs may also occur: sweating, clammy skin, anxiety, fast or increased heart beat, high blood pressure, awareness of your heart beat, sudden strong pain in the breast that may radiate into neighbouring areas (angina pectoris and cardiac arrhythmias)If blood sugar levels continue to drop you may suffer from considerable confusion (delirium), develop fits, lose self control, breathing may be shallow and your heart beat slowed down, you may fall into unconsciousness. The clinical picture of a severe reduced blood sugar level may resemble that of a stroke.

► Treating hypoglycaemia:

In most cases the signs of reduced blood sugar vanish very quickly when you consume some form of sugar, e.g. sugar cubes, sweet juice, sweetened tea.

You should therefore always take some form of sugar with you (e.g. sugar cubes). Remember that artificial sweeteners are not effective. Please contact your doctor or go to the hospital if taking sugar does not help or if the symptoms recur.

►Lab Tests

The level of sugar in your blood or urine should be checked regularly. Your doctor may also take blood tests to monitor your blood cell levels and liver function.

►Driving and using machines

Your ability to concentrate or react may be reduced if your blood sugar is lowered (hypoglycaemia), or raised (hyperglycaemia) or if you develop visual problems as a result of such conditions. Bear in mind that you could endanger yourself or others (e.g. when driving a car or using machines). Please ask your doctor whether you can drive a car if you:

• have frequent episodes of hypoglycaemia,
• have fewer or no warning signals of hypoglycaemia

POSSIBLE SIDE EFFECTS

Like all medicines, AMARYL can cause side effects, although not everybody gets them.

►Tell your doctor immediately if you experience any of the following symptoms:

• Allergic reactions (including inflammation of blood vessels, often with skin rash) which may develop into serious reactions with difficulty in breathing, fall in blood pressure and sometimes progressing to shock
• Abnormal liver function including yellowing of the skin and eyes (jaundice), problems with the bile flow (cholestasis), inflammation of the liver (hepatitis) or liver failure
• Allergy (hypersensitivity) of the skin such as itching, rash, hives and increased sensitivity to sun. Some mild allergic reactions may develop into serious reactions
• Severe hypoglycaemia including loss of consciousness, seizures or coma

►RARE SIDE EFFECTS (affects more than 1 patient in 10,000 and less than 1 patient in 1000 people):

• Lower blood sugar than normal (hypoglycaemia)
• Decrease in the number of blood cells:
• Blood platelets (which increases risk of bleeding or bruising)
• White blood cells (which makes infections more likely)
• Red blood cells (which can make the skin pale and cause weakness or breathlessness)

These problems generally get better after you stop taking AMARYL.

►VERY RARE SIDE EFFECTS (affects less than 1 patient in 10,000):

• Allergic reactions (including inflammation of blood vessels, often with skin rash) which may develop into serious reactions with difficulty in breathing, fall in blood pressure and sometimes progressing to shock. If you experience any of these symptoms, tell your doctor immediately
• Abnormal liver function including yellowing of the skin and eyes (jaundice), impairment of the bile flow (cholestasis), inflammation of the liver (hepatitis) or liver failure. If you experience any of these symptoms, tell your doctor immediately
• Feeling or being sick, diarrhoea, feeling full or bloated, and abdominal pain
• Decrease in the amount of sodium level in your blood (shown by blood tests)

►OTHER SIDE EFFECTS:

• Allergy (hypersensitivity) of the skin may occur such as itching, rash, hives and increased sensitivity to sun. Some mild allergic reactions may develop into serious reactions with swallowing or breathing problems, swelling of your lips, throat or tongue. Therefore in the event of one of these side effects, tell your doctor immediately
• Allergic reactions with sulfonylureas, sulfonamides, or related drugs may occur
• Problems with your sight may occur when beginning treatment with AMARYL. This is due to changes in blood sugar levels and should soon improve
• Increased liver enzymes

If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

DRUG INTERACTION

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.

Your doctor may wish to change your dose of AMARYL if you are taking other medicines, which may weaken or strengthen the effect of AMARYL on the level of sugar in your blood.

►The following medicines can increase the blood sugar lowering effect of AMARYL. This can lead to a risk of hypoglycaemia (low blood sugar):

• Other medicines to treat diabetes mellitus (such as insulin or metformin)
• Medicines to treat pain and inflammation (phenylbutazone, azopropazone, oxyphenbutazone, aspirin-like medicines)
• Medicines to treat urinary infections (such as some long acting sulfonamides)
• Medicines to treat bacterial and fungal infections (tetracyclines, chloramphenicol, fluconazole, miconazole, quinolones, clarithromycin)
• Medicines to inhibit blood clotting (coumarin derivatives such as warfarin)
• Medicines supporting muscle build up (anabolics)
• Medicines used for male sex hormone replacement therapy
• Medicines to treat depression (fluoxetine, MAO-inhibitors)
• Medicines lowering high cholesterol level (fibrates)
• Medicines lowering high blood pressure (ACE inhibitors)
• Medicines to treat gout (allopurinol, probenecid, sulfinpyrazone)
• Medicines to treat cancer (cyclophosphamide, ifosfamide, trofosfamide)
• Medicines used to reduce weight (fenfluramine)
• Medicines to increase circulation when given in a high dose intravenous infusion (pentoxifylline)
• Medicines to treat nasal allergies such as hay fever (tritoqualine)
• Medicines called sympatholytics to treat high blood pressure, heart failure, or prostate symptoms

►The following medicines may decrease the blood sugar lowering effect of AMARYL. This can lead to a risk of hyperglycaemia (high blood sugar level):

• Medicines containing female sex hormones (oestrogens, progestogens)
• Medicines to treat high blood pressure called thiazide diuretics (water tablets)
• Medicines used to stimulate the thyroid gland (such as levothyroxine)
• Medicines to treat allergies and inflammation (glucocorticoids)
• Medicines to treat severe mental disorders (chlorpromazine and other phenothiazine derivatives)
• Medicines used to raise heart beat, to treat asthma or nasal congestion, coughs and colds, used to reduce weight, or used in life-threatening emergencies (adrenaline and sympathomimetics)
• Medicines to treat high cholesterol level (nicotinic acid)
• Medicines to treat constipation when they are used long term (laxatives)
• Medicines to treat fits (phenytoin)
• Medicines to treat nervousness and sleep problems (barbiturates)
• Medicines to treat increased pressure in the eye (azetazolamide)
• Medicines to treat high blood pressure or lowering blood sugar (diazoxide)
• Medicines to treat infections, tuberculosis (rifampicine)
• Medicines to treat severe low blood sugar levels (glucagon)

►The following medicines can increase or decrease the blood sugar lowering effect of AMARYL:

• Medicines to treat stomach ulcers (called H2 antagonists)
• Medicines to treat high blood pressure or heart failure such as beta-blockers, clonidine, guanethidine and reserpine. These can also hide the signs of hypoglycaemia, so special care is needed when taking these medicines

►AMARYL may either increase or weaken the effects of the following medicines:

• Medicines inhibiting blood clotting (coumarin derivatives such as warfarin)