Aricept

Brand: ARICEPT

Generic: DONEPAZIL

ARICEPT (donepezil hydrochloride) belongs to a group of medicines called acetylcholinesterase inhibitors.

It is used to treat the symptoms of dementia in people diagnosed as having mild and moderately severe Alzheimer’s disease.  The symptoms include increasing memory loss, confusion and behavioral changes.  As a result, sufferers of Alzheimer’s disease find it more and more difficult to carry out their normal daily activities.

ARICEPT is for use in adult patients only.



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MEDICATION GUIDE

  Aircept Medication Guide (1.7 MiB, 31 hits)

SAFETY INFORMATION

►Do not take AIRCEPT if:

• you are allergic (hypersensitive) to donepezil hydrochloride, or to piperidine derivatives, or any of the other ingredients of ARICEPT
• you are breast-feeding

►Before taking AIRCEPT, tell your doctor if you have had:

• stomach or duodenal ulcers
• seizures (fits) or convulsions
• a heart condition (irregular or very slow heart beat)
• asthma or other long term lung disease
• liver problems or hepatitis
• difficulty passing urine or mild kidney disease
  Also tell your doctor if you are pregnant or think you might be pregnant.

►Other important information:

If you are going to have an operation that requires you to have a general anaesthetic, you should tell your doctor and the anaesthetist that you are taking ARICEPT.  This is because your medicine may affect the amount of anesthetic needed.

ARICEPT can be used in patients with kidney disease or mild to moderate liver disease.  Tell your doctor first if you have kidney or liver disease.  Patients with severe liver disease should not take ARICEPT.

►Taking ARICEPT with food and drink:

• Food will not influence the effect of ARICEPT.
• ARICEPT should not be taken with alcohol because alcohol may change its effect.

►Pregnancy and breast-feeding:

• ARICEPT must not be used while breastfeeding.
• If you are pregnant, or think you might be pregnant, ask your doctor for advice before taking any medicine.

►Driving and using machines

Alzheimer’s disease may impair your ability to drive or operate machinery and you must not perform these activities unless your doctor tells you that it is safe to do so.   Also, your medicine can cause tiredness, dizziness and muscle cramp.  If you experience any of these effects  you must not drive or operate machinery.

►Important information about some of the ingredients of ARICEPT

This medicine contains lactose.  If you have been told by your doctor that you have intolerance to some sugars, you should contact your doctor before taking ARICEPT.

POSSIBLE SIDE EFFECTS

Like all medicines, ARICEPT can cause side effects, although not everybody gets them. The following side effects have been reported by people taking ARICEPT. Tell your doctor if you have any of these effects while you are taking ARICEPT

►SERIOUS SIDE EFFECTS:

You must tell your doctor immediately if you notice these serious side effects mentioned.  You may need urgent medical treatment.

• liver damage e.g. hepatitis.  The symptoms of hepatitis are feeling or being sick, loss of appetite, feeling generally unwell, fever, itching, yellowing of the skin and eyes, and dark coloured urine (probably affecting fewer than 1 in 1,000)
• stomach or duodenal ulcers.  The symptoms of ulcers are stomach pain and discomfort (indigestion) felt between the navel and the breast bone (probably affecting fewer than 1 in 100)
• bleeding in the stomach or intestines. This may cause you to pass black tar like stools or visible blood from the rectum (probably affecting fewer than 1 in 100)
• seizures (fits) or convulsions (probably affecting fewer than 1 in 100)

►VERY COMMON SIDE EFFECTS (probably affecting more than 1 in 10):

• diarrhea
• feeling or being sick
• headaches

►COMMON SIDE EFFECTS (probably affecting up to 1 in 10):

• muscle cramp
• tiredness
• difficulty in sleeping (insomnia)
• the common cold
• loss of appetite
• hallucinations (seeing or hearing things that are not really there)
• agitation
• aggressive behavior
• fainting
• dizziness
• stomach feeling uncomfortable
• rash
• itching
• passing urine uncontrollably
• pain
• accidents (patients may be more prone to falls and accidental injury)

►UNCOMMON SIDE EFFECTS (probably affecting fewer than 1 in 100):

• slow heart beat

►RARE SIDE EFFECTS (probably affecting fewer than 1 in 1,000):

• stiffness, shaking or uncontrollable movement especially of the face and tongue but also of the limbs

DRUG INTERACTION

Please tell your doctor or pharmacist if you are taking, or have recently taken, any other medicine.  This includes medicines that your doctor has not prescribed for you but which you have bought yourself from a chemist/pharmacist.  It also applies to medicines you may take sometime in the future if you continue to take ARICEPT.  This is because these medicines may weaken or strengthen the effects of ARICEPT.

Especially tell your doctor if you are taking any of the following types of medicines:

• other Alzheimer’s disease medicines, e.g. galantamine
• pain killers or treatment for arthritis e.g. aspirin, non-steroidal anti-inflammatory (NSAID) drugs such as ibuprofen, or diclofenac sodium
• anticholinergics medicines, e.g. tolterodine
• antibiotics e.g. erythromycin, rifampicin
• anti-fungal medicine e.g. ketoconazole
• anti-depressants e.g. fluoxetine
• anticonvulsants e.g. phenytoin, carbamazepine
• medication for a heart condition e.g. quinidine, beta-blockers (propanolol and atenolol)
• muscle relaxants e.g. diazepam, succinylcholine
• general anesthetic
• medicines obtained without a prescription e.g. herbal remedies